I enjoyed the Dresden files in the beginning when they were very case of the week, but once they got into the massive war with the wizards and the vampires... yeah, I just didn't care. And I just couldn't like Harry. Although he eventually got his act together a little bit, he was the kind of character who foolishly rushes in to bad situations with no plan, even after that has proven disastrous multiple times before. I really hate characters who won't learn from their mistakes.

I'll have to check out the Rachel Harrison books. Like I said, I liked the setting, I just really didn't like Harry, so something in that vein might be fun.

Pratchett is hard to get into, you have to find the right character group to follow. It took me several books to really find the one I enjoyed, because I kept trying to read Wizards/Rincewind books and I don't really like those characters. But if you don't like the formatting either, that's definitely a barrier. I like the footnotes, I find them funny-- but I'm not an English major and never had to do any serious analysis of writing that would involve footnotes. And I can see how dyslexia wouldn't help either.

I haven't seen X-Files or Breaking Bad, so I can't comment there. But I wouldn't defend all of Pratchett anyway. I think his earlier work (standard fantasy laughing at itself) is much less enjoyable than the later books (satirizing modern life via a fantasy world) and there are some characters I flat-out don't care about and won't read.